Lessons from the Laureates

This paper uses as source material twenty-three autobiographical essays by Nobel economists presented since 1984 at Trinity University (San Antonio, Texas) and published in Lives of the Laureates (MIT Press). A goal of the lecture series is to enhance understanding of the link between biography and the development of modern economic thought. We explore this link and identify common themes in the essays, relying heavily on the words of the laureates. Common themes include the importance of real-world events coupled with a desire for rigor and relevance, the critical influence of teachers, the necessity of scholarly interaction, and the role of luck or happenstance. Most of the laureates view their research program not as one planned in advance but one that evolved via the marketplace for ideas.autobiography, Nobel economists, economic thought

E-BioFlow: Different Perspectives on Scientific Workflows

We introduce a new type of workflow design system called\ud e-BioFlow and illustrate it by means of a simple sequence alignment workflow. E-BioFlow, intended to model advanced scientific workflows, enables the user to model a workflow from three different but strongly coupled perspectives: the control flow perspective, the data flow perspective, and the resource perspective. All three perspectives are of\ud equal importance, but workflow designers from different domains prefer different perspectives as entry points for their design, and a single workflow designer may prefer different perspectives in different stages of workflow design. Each perspective provides its own type of information, visualisation and support for validation. Combining these three perspectives in a single application provides a new and flexible way of modelling workflows

Irreversible quantum graphs

Irreversibility is introduced to quantum graphs by coupling the graphs to a bath of harmonic oscillators. The interaction which is linear in the harmonic oscillator amplitudes is localized at the vertices. It is shown that for sufficiently strong coupling, the spectrum of the system admits a new continuum mode which exists even if the graph is compact, and a {\it single} harmonic oscillator is coupled to it. This mechanism is shown to imply that the quantum dynamics is irreversible. Moreover, it demonstrates the surprising result that irreversibility can be introduced by a "bath" which consists of a {\it single} harmonic oscillator

Bound state equation in the Wilson loop approach with minimal surfaces

The large-distance dynamics in quarkonium systems is investigated, in the large N limit, through the saturation of Wilson loop averages by minimal surfaces. Using a representation for the quark propagator in the presence of the external gluon field based on the use of path-ordered phase factors, a covariant three-dimensional bound state equation of the Breit-Salpeter type is derived, in which the interaction potentials are provided by the energy-momentum vector of the straight segment joining the quark to the antiquark and carrying a constant linear energy density, equal to the string tension. The interaction potentials are confining and reduce to the linear vector potential in the static case and receive, for moving quarks, contributions from the moments of inertia of the straight segment. The self-energy parts of the quark propagators induce spontaneous breakdown of chiral symmetry with a mechanism identical to that of the exchange of one Coulomb-gluon. The nonrelativistic and ultrarelativistic properties of the bound state spectrum are studied.Comment: 57 pages, 7 figure

AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival

Biomechanical strain imposed by age-related thickening of the basal lamina and augmented tissue stiffness in the prostate gland coincides with increased cancer risk. Here we hypothesized that the structural alterations in the basal lamina associated with age can induce mechanotransduction pathways in prostate epithelial cells (PECs) to promote invasiveness and cancer progression. To demonstrate this, we developed a 3D model of PEC acini in which thickening and stiffening of basal lamina matrix was induced by advanced glycation end-product (AGE)-dependent non-enzymatic crosslinking of its major components, collagen IV and laminin. We used this model to demonstrate that antibody targeted blockade of CTLD2, the second of eight C-type lectin-like domains in Endo180 (CD280, CLEC13E, KIAA0709, MRC2, TEM9, uPARAP) that can recognize glycosylated collagens, reversed actinomyosin-based contractility [myosin-light chain-2 (MLC2) phosphorylation], loss of cell polarity, loss of cell–cell junctions, luminal infiltration and basal invasion induced by AGE-modified basal lamina matrix in PEC acini. Our in vitro results were concordant with luminal occlusion of acini in the prostate glands of adult Endo180ΔEx2–6/ΔEx2–6 mice, with constitutively exposed CTLD2 and decreased survival of men with early (non-invasive) prostate cancer with high epithelial Endo180 expression and levels of AGE. These findings indicate that AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed PECs via a molecular mechanism linked to cancer progression. This study provides a rationale for targeting CTLD2 in Endo180 in prostate cancer and other pathologies in which increased basal lamina thickness and tissue stiffness are driving factors

Dynamical Evolution of Boson Stars II: Excited States and Self-Interacting Fields

The dynamical evolution of self-gravitating scalar field configurations in numerical relativity is studied. The previous analysis on ground state boson stars of non-interacting fields is extended to excited states and to fields with self couplings. Self couplings can significantly change the physical dimensions of boson stars, making them much more astrophysically interesting (e.g., having mass of order 0.1 solar mass). The stable ($S$) and unstable ($U$) branches of equilibrium configurations of boson stars of self-interacting fields are studied; their behavior under perturbations and their quasi-normal oscillation frequencies are determined and compared to the non-interacting case. Excited states of boson stars with and without self-couplings are studied and compared. Excited states also have equilibrium configurations with $S$ and $U$ branch structures; both branches are intrinsically unstable under a generic perturbation but have very different instability time scales. We carried out a detailed study of the instability time scales of these configurations. It is found that highly excited states spontaneously decay through a cascade of intermediate states similar to atomic transitions.Comment: 16 pages+ 13 figures . All figures are available at http://wugrav.wustl.edu/Paper